Identification of 4-(3-Pyridyl)-4-oxobutyl-2′-deoxycytidine Adducts Formed in the Reaction of DNA with 4-(Acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone: A Chemically Activated Form of Tobacco-Specific Carcinogens

[Image: see text] Metabolic activation of the carcinogenic tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK, 1) and N′-nitrosonornicotine (NNN, 2) results in the formation of 4-(3-pyridyl)-4-oxobutyl (POB)-DNA adducts, several of which have been previously identified...

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Detalles Bibliográficos
Autores principales: Michel, Anna K., Zarth, Adam T., Upadhyaya, Pramod, Hecht, Stephen S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5377278/
https://www.ncbi.nlm.nih.gov/pubmed/28393135
http://dx.doi.org/10.1021/acsomega.7b00072

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5377278/
https://www.ncbi.nlm.nih.gov/pubmed/28393135
http://dx.doi.org/10.1021/acsomega.7b00072

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