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AZD0530 sensitizes drug‐resistant ALK‐positive lung cancer cells by inhibiting SRC signaling

Most tumors develop resistance to targeted cancer drugs, even though these drugs have produced substantial clinical responses. Here we established anaplastic lymphoma kinase (ALK)‐positive drug‐resistant lung cancer cell lines, which are resistant to ceritinib (LDK378). We found that ceritinib treat...

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Detalles Bibliográficos
Autores principales: Zhao, Yi, Yang, Yi, Xu, Yunhua, Lu, Shun, Jian, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5377386/
https://www.ncbi.nlm.nih.gov/pubmed/28396832
http://dx.doi.org/10.1002/2211-5463.12162