Using a biologically annotated library to analyze the anticancer mechanism of serine palmitoyl transferase (SPT) inhibitors

Mechanistic understanding is crucial to anticancer drug discovery. Here, we reveal that inhibition of serine palmitoyl transferase (SPT), the rate‐limiting enzyme in sphingolipid synthesis, induced death in a lung cancer cell line via a necrosis‐dependent pathway. To elucidate the mechanism of cell...

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Detalles Bibliográficos
Autores principales: Sano, Osamu, Kazetani, Ken‐ichi, Adachi, Ryutaro, Kurasawa, Osamu, Kawamoto, Tomohiro, Iwata, Hidehisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5377399/
https://www.ncbi.nlm.nih.gov/pubmed/28396835
http://dx.doi.org/10.1002/2211-5463.12196

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5377399/
https://www.ncbi.nlm.nih.gov/pubmed/28396835
http://dx.doi.org/10.1002/2211-5463.12196

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