Cochlear gene therapy with ancestral AAV in adult mice: complete transduction of inner hair cells without cochlear dysfunction

The use of viral vectors for inner ear gene therapy is receiving increased attention for treatment of genetic hearing disorders. Most animal studies to date have injected viral suspensions into neonatal ears, via the round window membrane. Achieving transduction of hair cells, or sensory neurons, th...

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Detalles Bibliográficos
Autores principales: Suzuki, Jun, Hashimoto, Ken, Xiao, Ru, Vandenberghe, Luk H., Liberman, M. Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5377419/
https://www.ncbi.nlm.nih.gov/pubmed/28367981
http://dx.doi.org/10.1038/srep45524

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5377419/
https://www.ncbi.nlm.nih.gov/pubmed/28367981
http://dx.doi.org/10.1038/srep45524

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