The Startle Disease Mutation E103K Impairs Activation of Human Homomeric α1 Glycine Receptors by Disrupting an Intersubunit Salt Bridge across the Agonist Binding Site

Glycine receptors (GlyR) belong to the pentameric ligand-gated ion channel (pLGIC) superfamily and mediate fast inhibitory transmission in the vertebrate CNS. Disruption of glycinergic transmission by inherited mutations produces startle disease in man. Many startle mutations are in GlyRs and provid...

Descripción completa

Detalles Bibliográficos
Autores principales: Safar, Fatemah, Hurdiss, Elliot, Erotocritou, Marios, Greiner, Timo, Lape, Remigijus, Irvine, Mark W., Fang, Guangyu, Jane, David, Yu, Rilei, Dämgen, Marc A., Biggin, Philip C., Sivilotti, Lucia G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2017
Materias:
Neurobiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5377815/
https://www.ncbi.nlm.nih.gov/pubmed/28174298
http://dx.doi.org/10.1074/jbc.M116.767616

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5377815/
https://www.ncbi.nlm.nih.gov/pubmed/28174298
http://dx.doi.org/10.1074/jbc.M116.767616

Ejemplares similares