Structural heterogeneity of the μ-opioid receptor’s conformational ensemble in the apo state

G-protein coupled receptors (GPCRs) are the largest and most pharmaceutically relevant family of membrane proteins. Here, fully unbiased, enhanced sampling simulations of a constitutively active mutant (CAM) of a class A GPCR, the μ-opioid receptor (μOR), demonstrates repeated transitions between th...

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Detalles Bibliográficos
Autores principales: Sena, Diniz M., Cong, Xiaojing, Giorgetti, Alejandro, Kless, Achim, Carloni, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5377942/
https://www.ncbi.nlm.nih.gov/pubmed/28368046
http://dx.doi.org/10.1038/srep45761

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5377942/
https://www.ncbi.nlm.nih.gov/pubmed/28368046
http://dx.doi.org/10.1038/srep45761

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