Critical threshold levels of DNA methyltransferase 1 are required to maintain DNA methylation across the genome in human cancer cells

Reversing DNA methylation abnormalities and associated gene silencing, through inhibiting DNA methyltransferases (DNMTs) is an important potential cancer therapy paradigm. Maximizing this potential requires defining precisely how these enzymes maintain genome-wide, cancer-specific DNA methylation. T...

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Detalles Bibliográficos
Autores principales: Cai, Yi, Tsai, Hsing-Chen, Yen, Ray-Whay Chiu, Zhang, Yang W., Kong, Xiangqian, Wang, Wei, Xia, Limin, Baylin, Stephen B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378172/
https://www.ncbi.nlm.nih.gov/pubmed/28232479
http://dx.doi.org/10.1101/gr.208108.116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378172/
https://www.ncbi.nlm.nih.gov/pubmed/28232479
http://dx.doi.org/10.1101/gr.208108.116

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