In vivo binding of PRDM9 reveals interactions with noncanonical genomic sites

In mouse and human meiosis, DNA double-strand breaks (DSBs) initiate homologous recombination and occur at specific sites called hotspots. The localization of these sites is determined by the sequence-specific DNA binding domain of the PRDM9 histone methyl transferase. Here, we performed an extensiv...

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Detalles Bibliográficos
Autores principales: Grey, Corinne, Clément, Julie A.J., Buard, Jérôme, Leblanc, Benjamin, Gut, Ivo, Gut, Marta, Duret, Laurent, de Massy, Bernard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378176/
https://www.ncbi.nlm.nih.gov/pubmed/28336543
http://dx.doi.org/10.1101/gr.217240.116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378176/
https://www.ncbi.nlm.nih.gov/pubmed/28336543
http://dx.doi.org/10.1101/gr.217240.116

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