Activation of MMP‐9 by membrane type‐1 MMP/MMP‐2 axis stimulates tumor metastasis

An artificial receptor for proMMP‐9 was created by fusing tissue inhibitor of MMP‐1 (TIMP‐1) with type II transmembrane mosaic serine protease (MSP‐T1). Expression of MSP‐T1 in 293T cells induced binding of proMMP‐9, which was processed by MMP‐2 activated by membrane type 1 MMP (MT1‐MMP). HT1080 cel...

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Detalles Bibliográficos
Autores principales: Li, Zichen, Takino, Takahisa, Endo, Yoshio, Sato, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378257/
https://www.ncbi.nlm.nih.gov/pubmed/27987367
http://dx.doi.org/10.1111/cas.13134

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378257/
https://www.ncbi.nlm.nih.gov/pubmed/27987367
http://dx.doi.org/10.1111/cas.13134

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