WP1066 suppresses macrophage cell death induced by inflammasome agonists independently of its inhibitory effect on STAT3

The compound WP1066 was originally synthesized by modifying the structure of AG490, which inhibits the activation of signal transducer and activator of transcription 3 (STAT3) by directly targeting Janus kinases (JAKs). WP1066 exhibits stronger anti‐cancer activity than AG490 against malignant gliom...

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Detalles Bibliográficos
Autores principales: Honda, Shino, Sadatomi, Daichi, Yamamura, Yasuo, Nakashioya, Kazutaka, Tanimura, Susumu, Takeda, Kohsuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378283/
https://www.ncbi.nlm.nih.gov/pubmed/28035720
http://dx.doi.org/10.1111/cas.13154

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378283/
https://www.ncbi.nlm.nih.gov/pubmed/28035720
http://dx.doi.org/10.1111/cas.13154

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