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An adaptive design for updating the threshold value of a continuous biomarker

Potential predictive biomarkers are often measured on a continuous scale, but in practice, a threshold value to divide the patient population into biomarker ‘positive’ and ‘negative’ is desirable. Early phase clinical trials are increasingly using biomarkers for patient selection, but at this stage,...

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Detalles Bibliográficos
Autores principales: Spencer, Amy V., Harbron, Chris, Mander, Adrian, Wason, James, Peers, Ian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378309/
https://www.ncbi.nlm.nih.gov/pubmed/27417407
http://dx.doi.org/10.1002/sim.7042