Using simulation to aid trial design: Ring-vaccination trials

BACKGROUND: The 2014–6 West African Ebola epidemic highlights the need for rigorous, rapid clinical trial methods for vaccines. A challenge for trial design is making sample size calculations based on incidence within the trial, total vaccine effect, and intracluster correlation, when these paramete...

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Detalles Bibliográficos
Autores principales: Hitchings, Matt David Thomas, Grais, Rebecca Freeman, Lipsitch, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378415/
https://www.ncbi.nlm.nih.gov/pubmed/28328984
http://dx.doi.org/10.1371/journal.pntd.0005470

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378415/
https://www.ncbi.nlm.nih.gov/pubmed/28328984
http://dx.doi.org/10.1371/journal.pntd.0005470

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