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Using simulation to aid trial design: Ring-vaccination trials
BACKGROUND: The 2014–6 West African Ebola epidemic highlights the need for rigorous, rapid clinical trial methods for vaccines. A challenge for trial design is making sample size calculations based on incidence within the trial, total vaccine effect, and intracluster correlation, when these paramete...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378415/ https://www.ncbi.nlm.nih.gov/pubmed/28328984 http://dx.doi.org/10.1371/journal.pntd.0005470 |