Cargando…
Crystal structure and dynamics of a lipid-induced potential desensitized-state of a pentameric ligand-gated channel
Desensitization in pentameric ligand-gated ion channels plays an important role in regulating neuronal excitability. Here, we show that docosahexaenoic acid (DHA), a key ω−3 polyunsaturated fatty acid in synaptic membranes, enhances the agonist-induced transition to the desensitized state in the pro...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2017
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378477/ https://www.ncbi.nlm.nih.gov/pubmed/28262093 http://dx.doi.org/10.7554/eLife.23886 |