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Crystal structure and dynamics of a lipid-induced potential desensitized-state of a pentameric ligand-gated channel

Desensitization in pentameric ligand-gated ion channels plays an important role in regulating neuronal excitability. Here, we show that docosahexaenoic acid (DHA), a key ω−3 polyunsaturated fatty acid in synaptic membranes, enhances the agonist-induced transition to the desensitized state in the pro...

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Detalles Bibliográficos
Autores principales:	Basak, Sandip, Schmandt, Nicolaus, Gicheru, Yvonne, Chakrapani, Sudha
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2017
Materias:	Biophysics and Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378477/ https://www.ncbi.nlm.nih.gov/pubmed/28262093 http://dx.doi.org/10.7554/eLife.23886

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