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ZEB1 Induces LOXL2-Mediated Collagen Stabilization and Deposition in the Extracellular Matrix to Drive Lung Cancer Invasion and Metastasis
Lung cancer is the leading cause of cancer-related death, primarily due to distant metastatic disease. Metastatic lung cancer cells can undergo an epithelial-to-mesenchymal transition (EMT) regulated by many transcription factors, including double-negative feedback loop between the microRNA-200 (miR...
Autores principales: | Peng, David H., Ungewiss, Christin, Tong, Pan, Byers, Lauren A., Wang, Jing, Canales, Jaime Rodriguez, Villalobos, Pamela A., Uraoka, Naohiro, Mino, Barbara, Behrens, Carmen, Wistuba, Ignacio I., Han, Richard I, Wanna, Charles A., Fahrenholtz, Monica, Grande-Allen, Kathryn Jane, Creighton, Chad J., Gibbons, Don L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378666/ https://www.ncbi.nlm.nih.gov/pubmed/27694892 http://dx.doi.org/10.1038/onc.2016.358 |
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