FKBP12 enhances sensitivity to chemotherapy-induced cancer cell apoptosis by inhibiting MDM2

The FK506-binding protein 12 (FKBP12) is a cytoplasmic protein and has been reported to possess multiple functions in signaling transduction based on its interaction with different cellular targets. Here, we report that FKBP12 interacts with oncoprotein MDM2 and induces MDM2 degradation. We demonstr...

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Detalles Bibliográficos
Autores principales: Liu, T, Xiong, J, Yi, S, Zhang, H, Zhou, S, Gu, L, Zhou, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378873/
https://www.ncbi.nlm.nih.gov/pubmed/27617579
http://dx.doi.org/10.1038/onc.2016.331

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378873/
https://www.ncbi.nlm.nih.gov/pubmed/27617579
http://dx.doi.org/10.1038/onc.2016.331

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