Inhibition of Polo-like kinase 1 during the DNA damage response is mediated through loss of Aurora A recruitment by Bora

When cells in G2 phase are challenged with DNA damage, several key mitotic regulators such as Cdk1/Cyclin B, Aurora A and Plk1 are inhibited to prevent entry into mitosis. Here we have studied how inhibition of Plk1 is established after DNA damage. Using a Förster resonance energy transfer (FRET)-ba...

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Detalles Bibliográficos
Autores principales: Bruinsma, W, Aprelia, M, García-Santisteban, I, Kool, J, Xu, Y J, Medema, R H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378932/
https://www.ncbi.nlm.nih.gov/pubmed/27721411
http://dx.doi.org/10.1038/onc.2016.347

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378932/
https://www.ncbi.nlm.nih.gov/pubmed/27721411
http://dx.doi.org/10.1038/onc.2016.347

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