The structure of Zika virus NS5 reveals a conserved domain conformation

The recent outbreak of Zika virus (ZIKV) has imposed a serious threat to public health. Here we report the crystal structure of the ZIKV NS5 protein in complex with S-adenosyl-L-homocysteine, in which the tandem methyltransferase (MTase) and RNA-dependent RNA polymerase (RdRp) domains stack into one...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Boxiao, Tan, Xiao-Feng, Thurmond, Stephanie, Zhang, Zhi-Min, Lin, Asher, Hai, Rong, Song, Jikui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378951/
https://www.ncbi.nlm.nih.gov/pubmed/28345600
http://dx.doi.org/10.1038/ncomms14763

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378951/
https://www.ncbi.nlm.nih.gov/pubmed/28345600
http://dx.doi.org/10.1038/ncomms14763

Ejemplares similares