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The structure of Zika virus NS5 reveals a conserved domain conformation

The recent outbreak of Zika virus (ZIKV) has imposed a serious threat to public health. Here we report the crystal structure of the ZIKV NS5 protein in complex with S-adenosyl-L-homocysteine, in which the tandem methyltransferase (MTase) and RNA-dependent RNA polymerase (RdRp) domains stack into one...

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Detalles Bibliográficos
Autores principales:	Wang, Boxiao, Tan, Xiao-Feng, Thurmond, Stephanie, Zhang, Zhi-Min, Lin, Asher, Hai, Rong, Song, Jikui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378951/ https://www.ncbi.nlm.nih.gov/pubmed/28345600 http://dx.doi.org/10.1038/ncomms14763

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