Macrophages induce AKT/β-catenin-dependent Lgr5(+) stem cell activation and hair follicle regeneration through TNF

Skin stem cells can regenerate epidermal appendages; however, hair follicles (HF) lost as a result of injury are barely regenerated. Here we show that macrophages in wounds activate HF stem cells, leading to telogen–anagen transition (TAT) around the wound and de novo HF regeneration, mostly through...

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Detalles Bibliográficos
Autores principales: Wang, Xusheng, Chen, Haiyan, Tian, Ruiyun, Zhang, Yiling, Drutskaya, Marina S., Wang, Chengmei, Ge, Jianfeng, Fan, Zhimeng, Kong, Deqiang, Wang, Xiaoxiao, Cai, Ting, Zhou, Ying, Wang, Jingwen, Wang, Jinmei, Wang, Shan, Qin, Zhihai, Jia, Huanhuan, Wu, Yue, Liu, Jia, Nedospasov, Sergei A., Tredget, Edward E., Lin, Mei, Liu, Jianjun, Jiang, Yuyang, Wu, Yaojiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378973/
https://www.ncbi.nlm.nih.gov/pubmed/28345588
http://dx.doi.org/10.1038/ncomms14091

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378973/
https://www.ncbi.nlm.nih.gov/pubmed/28345588
http://dx.doi.org/10.1038/ncomms14091

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