Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression

Despite a high degree of homology, insulin receptor (IR) and IGF-1 receptor (IGF1R) mediate distinct cellular and physiological functions. Here, we demonstrate how domain differences between IR and IGF1R contribute to the distinct functions of these receptors using chimeric and site-mutated receptor...

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Detalles Bibliográficos
Autores principales: Cai, Weikang, Sakaguchi, Masaji, Kleinridders, Andre, Gonzalez-Del Pino, Gonzalo, Dreyfuss, Jonathan M., O'Neill, Brian T., Ramirez, Alfred K., Pan, Hui, Winnay, Jonathon N., Boucher, Jeremie, Eck, Michael J., Kahn, C. Ronald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378997/
https://www.ncbi.nlm.nih.gov/pubmed/28345670
http://dx.doi.org/10.1038/ncomms14892

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378997/
https://www.ncbi.nlm.nih.gov/pubmed/28345670
http://dx.doi.org/10.1038/ncomms14892

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