A redox-mediated Kemp eliminase

The acid/base-catalysed Kemp elimination of 5-nitro-benzisoxazole forming 2-cyano-4-nitrophenol has long served as a design platform of enzymes with non-natural reactions, providing new mechanistic insights in protein science. Here we describe an alternative concept based on redox catalysis by P450-...

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Detalles Bibliográficos
Autores principales: Li, Aitao, Wang, Binju, Ilie, Adriana, Dubey, Kshatresh D., Bange, Gert, Korendovych, Ivan V., Shaik, Sason, Reetz, Manfred T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379065/
https://www.ncbi.nlm.nih.gov/pubmed/28348375
http://dx.doi.org/10.1038/ncomms14876

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379065/
https://www.ncbi.nlm.nih.gov/pubmed/28348375
http://dx.doi.org/10.1038/ncomms14876

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