Inhibiting the system x(C)(−)/glutathione axis selectively targets cancers with mutant-p53 accumulation

TP53, a critical tumour suppressor gene, is mutated in over half of all cancers resulting in mutant-p53 protein accumulation and poor patient survival. Therapeutic strategies to target mutant-p53 cancers are urgently needed. We show that accumulated mutant-p53 protein suppresses the expression of SL...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, David S., Duong, Cuong P., Haupt, Sue, Montgomery, Karen G., House, Colin M., Azar, Walid J., Pearson, Helen B., Fisher, Oliver M., Read, Matthew, Guerra, Glen R., Haupt, Ygal, Cullinane, Carleen, Wiman, Klas G., Abrahmsen, Lars, Phillips, Wayne A., Clemons, Nicholas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379068/
https://www.ncbi.nlm.nih.gov/pubmed/28348409
http://dx.doi.org/10.1038/ncomms14844

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379068/
https://www.ncbi.nlm.nih.gov/pubmed/28348409
http://dx.doi.org/10.1038/ncomms14844

Ejemplares similares