Allosteric cross-talk in chromatin can mediate drug-drug synergy

Exploitation of drug–drug synergism and allostery could yield superior therapies by capitalizing on the immensely diverse, but highly specific, potential associated with the biological macromolecular landscape. Here we describe a drug–drug synergy mediated by allosteric cross-talk in chromatin, wher...

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Detalles Bibliográficos
Autores principales: Adhireksan, Zenita, Palermo, Giulia, Riedel, Tina, Ma, Zhujun, Muhammad, Reyhan, Rothlisberger, Ursula, Dyson, Paul J., Davey, Curt A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379107/
https://www.ncbi.nlm.nih.gov/pubmed/28358030
http://dx.doi.org/10.1038/ncomms14860

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379107/
https://www.ncbi.nlm.nih.gov/pubmed/28358030
http://dx.doi.org/10.1038/ncomms14860

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