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PKA phosphorylation reshapes the pharmacological kinetics of BmK AS, a unique site-4 sodium channel-specific modulator

Although modulation of the activity of voltage-gated sodium channels (VGSCs) by protein kinase A (PKA) phosphorylation has been investigated in multiple preparations, the pharmacological sensitivity of VGSCs to scorpion toxins after PKA phosphorylation has rarely been approached. In this study, the...

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Detalles Bibliográficos
Autores principales: Liu, Z. R., Zhang, H., Wu, J. Q., Zhou, J. J., Ji, Y. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379197/
https://www.ncbi.nlm.nih.gov/pubmed/24430351
http://dx.doi.org/10.1038/srep03721