A Gate Hinge Controls the Epithelial Calcium Channel TRPV5

TRPV5 is unique within the large TRP channel family for displaying a high Ca(2+) selectivity together with Ca(2+)-dependent inactivation. Our study aims to uncover novel insights into channel gating through in-depth structure-function analysis. We identify an exceptional tryptophan (W583) at the ter...

Descripción completa

Detalles Bibliográficos
Autores principales: van der Wijst, Jenny, Leunissen, Elizabeth H., Blanchard, Maxime G., Venselaar, Hanka, Verkaart, Sjoerd, Paulsen, Candice E., Bindels, René J., Hoenderop, Joost G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379628/
https://www.ncbi.nlm.nih.gov/pubmed/28374795
http://dx.doi.org/10.1038/srep45489

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379628/
https://www.ncbi.nlm.nih.gov/pubmed/28374795
http://dx.doi.org/10.1038/srep45489

Ejemplares similares