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A Gate Hinge Controls the Epithelial Calcium Channel TRPV5

TRPV5 is unique within the large TRP channel family for displaying a high Ca(2+) selectivity together with Ca(2+)-dependent inactivation. Our study aims to uncover novel insights into channel gating through in-depth structure-function analysis. We identify an exceptional tryptophan (W583) at the ter...

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Detalles Bibliográficos
Autores principales:	van der Wijst, Jenny, Leunissen, Elizabeth H., Blanchard, Maxime G., Venselaar, Hanka, Verkaart, Sjoerd, Paulsen, Candice E., Bindels, René J., Hoenderop, Joost G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379628/ https://www.ncbi.nlm.nih.gov/pubmed/28374795 http://dx.doi.org/10.1038/srep45489

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