Mechanistic Investigations of the Mitochondrial Complex I Inhibitor Rotenone in the Context of Pharmacological and Safety Evaluation

Inhibitors of the mitochondrial respiratory chain complex I are suggested to exert anti-tumor activity on those tumors relying on oxidative metabolism and are therefore of interest to oncology research. Nevertheless, the safety profile of these inhibitors should be thoroughly assessed. Rotenone, a p...

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Detalles Bibliográficos
Autores principales: Heinz, Sabrina, Freyberger, Alexius, Lawrenz, Bettina, Schladt, Ludwig, Schmuck, Gabriele, Ellinger-Ziegelbauer, Heidrun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379642/
https://www.ncbi.nlm.nih.gov/pubmed/28374803
http://dx.doi.org/10.1038/srep45465

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379642/
https://www.ncbi.nlm.nih.gov/pubmed/28374803
http://dx.doi.org/10.1038/srep45465

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