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Dietary inflammatory index and risk of first myocardial infarction; a prospective population-based study
BACKGROUND: Chronic, low-grade inflammation is an established risk factor for cardiovascular disease. The inflammatory impact of diet can be reflected by concentrations of inflammatory markers in the bloodstream and the inflammatory potential of diet can be estimated by the dietary inflammatory inde...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379659/ https://www.ncbi.nlm.nih.gov/pubmed/28376792 http://dx.doi.org/10.1186/s12937-017-0243-8 |
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author | Bodén, Stina Wennberg, Maria Van Guelpen, Bethany Johansson, Ingegerd Lindahl, Bernt Andersson, Jonas Shivappa, Nitin Hebert, James R. Nilsson, Lena Maria |
author_facet | Bodén, Stina Wennberg, Maria Van Guelpen, Bethany Johansson, Ingegerd Lindahl, Bernt Andersson, Jonas Shivappa, Nitin Hebert, James R. Nilsson, Lena Maria |
author_sort | Bodén, Stina |
collection | PubMed |
description | BACKGROUND: Chronic, low-grade inflammation is an established risk factor for cardiovascular disease. The inflammatory impact of diet can be reflected by concentrations of inflammatory markers in the bloodstream and the inflammatory potential of diet can be estimated by the dietary inflammatory index (DII(TM)), which has been associated with cardiovascular disease risk in some previous studies. We aimed to examine the association between the DII and the risk of first myocardial infarction (MI) in a population-based study with long follow-up. METHOD: We conducted a prospective case–control study of 1389 verified cases of first MI and 5555 matched controls nested within the population-based cohorts of the Northern Sweden Health and Disease Study (NSHDS), of which the largest is the ongoing Västerbotten Intervention Programme (VIP) with nearly 100 000 participants during the study period. Median follow-up from recruitment to MI diagnosis was 6.4 years (6.2 for men and 7.2 for women). DII scores were derived from a validated food frequency questionnaire (FFQ) administered in 1986–2006. Multivariable conditional logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI), using quartile 1 (most anti-inflammatory diet) as the reference category. For validation, general linear models were used to estimate the association between the DII scores and two inflammatory markers, high-sensitivity C-reactive protein (hsCRP) and interleukin 6 (IL-6) in a subset (n = 605) of the study population. RESULTS: Male participants with the most pro-inflammatory DII scores had an increased risk of MI [OR(Q4vsQ1) = 1.57 (95% CI 1.21–2.02) P (trend) = 0.02], which was essentially unchanged after adjustment for potential confounders, including cardiovascular risk factors [OR(Q4vsQ1) = 1.50 (95% CI 1.14–1.99), P (trend) = 0.10]. No association was found between DII and MI in women. An increase of one DII score unit was associated with 9% higher hsCRP (95% CI 0.03–0.14) and 6% higher IL-6 (95% CI 0.02–0.11) in 605 controls with biomarker data available. CONCLUSION: A pro-inflammatory diet was associated with an elevated risk of first myocardial infarction in men; whereas for women the relationship was null. Consideration of the inflammatory impact of diet could improve prevention of cardiovascular disease. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12937-017-0243-8) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-5379659 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-53796592017-04-07 Dietary inflammatory index and risk of first myocardial infarction; a prospective population-based study Bodén, Stina Wennberg, Maria Van Guelpen, Bethany Johansson, Ingegerd Lindahl, Bernt Andersson, Jonas Shivappa, Nitin Hebert, James R. Nilsson, Lena Maria Nutr J Research BACKGROUND: Chronic, low-grade inflammation is an established risk factor for cardiovascular disease. The inflammatory impact of diet can be reflected by concentrations of inflammatory markers in the bloodstream and the inflammatory potential of diet can be estimated by the dietary inflammatory index (DII(TM)), which has been associated with cardiovascular disease risk in some previous studies. We aimed to examine the association between the DII and the risk of first myocardial infarction (MI) in a population-based study with long follow-up. METHOD: We conducted a prospective case–control study of 1389 verified cases of first MI and 5555 matched controls nested within the population-based cohorts of the Northern Sweden Health and Disease Study (NSHDS), of which the largest is the ongoing Västerbotten Intervention Programme (VIP) with nearly 100 000 participants during the study period. Median follow-up from recruitment to MI diagnosis was 6.4 years (6.2 for men and 7.2 for women). DII scores were derived from a validated food frequency questionnaire (FFQ) administered in 1986–2006. Multivariable conditional logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI), using quartile 1 (most anti-inflammatory diet) as the reference category. For validation, general linear models were used to estimate the association between the DII scores and two inflammatory markers, high-sensitivity C-reactive protein (hsCRP) and interleukin 6 (IL-6) in a subset (n = 605) of the study population. RESULTS: Male participants with the most pro-inflammatory DII scores had an increased risk of MI [OR(Q4vsQ1) = 1.57 (95% CI 1.21–2.02) P (trend) = 0.02], which was essentially unchanged after adjustment for potential confounders, including cardiovascular risk factors [OR(Q4vsQ1) = 1.50 (95% CI 1.14–1.99), P (trend) = 0.10]. No association was found between DII and MI in women. An increase of one DII score unit was associated with 9% higher hsCRP (95% CI 0.03–0.14) and 6% higher IL-6 (95% CI 0.02–0.11) in 605 controls with biomarker data available. CONCLUSION: A pro-inflammatory diet was associated with an elevated risk of first myocardial infarction in men; whereas for women the relationship was null. Consideration of the inflammatory impact of diet could improve prevention of cardiovascular disease. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12937-017-0243-8) contains supplementary material, which is available to authorized users. BioMed Central 2017-04-04 /pmc/articles/PMC5379659/ /pubmed/28376792 http://dx.doi.org/10.1186/s12937-017-0243-8 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Bodén, Stina Wennberg, Maria Van Guelpen, Bethany Johansson, Ingegerd Lindahl, Bernt Andersson, Jonas Shivappa, Nitin Hebert, James R. Nilsson, Lena Maria Dietary inflammatory index and risk of first myocardial infarction; a prospective population-based study |
title | Dietary inflammatory index and risk of first myocardial infarction; a prospective population-based study |
title_full | Dietary inflammatory index and risk of first myocardial infarction; a prospective population-based study |
title_fullStr | Dietary inflammatory index and risk of first myocardial infarction; a prospective population-based study |
title_full_unstemmed | Dietary inflammatory index and risk of first myocardial infarction; a prospective population-based study |
title_short | Dietary inflammatory index and risk of first myocardial infarction; a prospective population-based study |
title_sort | dietary inflammatory index and risk of first myocardial infarction; a prospective population-based study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379659/ https://www.ncbi.nlm.nih.gov/pubmed/28376792 http://dx.doi.org/10.1186/s12937-017-0243-8 |
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