FUS inclusions disrupt RNA localization by sequestering kinesin-1 and inhibiting microtubule detyrosination

Cytoplasmic inclusions of the RNA-binding protein fused in sarcoma (FUS) represent one type of membraneless ribonucleoprotein compartment. Formation of FUS inclusions is promoted by amyotrophic lateral sclerosis (ALS)–linked mutations, but the cellular functions affected upon inclusion formation are...

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Detalles Bibliográficos
Autores principales: Yasuda, Kyota, Clatterbuck-Soper, Sarah F., Jackrel, Meredith E., Shorter, James, Mili, Stavroula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379945/
https://www.ncbi.nlm.nih.gov/pubmed/28298410
http://dx.doi.org/10.1083/jcb.201608022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379945/
https://www.ncbi.nlm.nih.gov/pubmed/28298410
http://dx.doi.org/10.1083/jcb.201608022

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