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FUS inclusions disrupt RNA localization by sequestering kinesin-1 and inhibiting microtubule detyrosination
Cytoplasmic inclusions of the RNA-binding protein fused in sarcoma (FUS) represent one type of membraneless ribonucleoprotein compartment. Formation of FUS inclusions is promoted by amyotrophic lateral sclerosis (ALS)–linked mutations, but the cellular functions affected upon inclusion formation are...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379945/ https://www.ncbi.nlm.nih.gov/pubmed/28298410 http://dx.doi.org/10.1083/jcb.201608022 |