Cargando…
Telomere-driven diseases and telomere-targeting therapies
Telomeres, the protective ends of linear chromosomes, shorten throughout an individual’s lifetime. Telomere shortening is proposed to be a primary molecular cause of aging. Short telomeres block the proliferative capacity of stem cells, affecting their potential to regenerate tissues, and trigger th...
Autores principales: | Martínez, Paula, Blasco, Maria A. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379954/ https://www.ncbi.nlm.nih.gov/pubmed/28254828 http://dx.doi.org/10.1083/jcb.201610111 |
Ejemplares similares
-
A ‘higher order' of telomere regulation: telomere heterochromatin and telomeric RNAs
por: Schoeftner, Stefan, et al.
Publicado: (2009) -
Telomeres in cancer therapy
por: Blasco, María A
Publicado: (2001) -
Telomeres and telomerase as therapeutic targets to prevent and treat age-related diseases
por: Bär, Christian, et al.
Publicado: (2016) -
Telomeric RNAs are essential to maintain telomeres
por: Montero, Juan José, et al.
Publicado: (2016) -
ATR suppresses telomere fragility and recombination but is dispensable for elongation of short telomeres by telomerase
por: McNees, Carolyn J., et al.
Publicado: (2010)