Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death

Glutamate is the dominant excitatory neurotransmitter in the brain, but under conditions of metabolic stress it can accumulate to excitotoxic levels. Although pharmacologic modulation of excitatory amino acid receptors is well studied, minimal consideration has been given to targeting mitochondrial...

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Detalles Bibliográficos
Autores principales: Divakaruni, Ajit S., Wallace, Martina, Buren, Caodu, Martyniuk, Kelly, Andreyev, Alexander Y., Li, Edward, Fields, Jerel A., Cordes, Thekla, Reynolds, Ian J., Bloodgood, Brenda L., Raymond, Lynn A., Metallo, Christian M., Murphy, Anne N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379957/
https://www.ncbi.nlm.nih.gov/pubmed/28254829
http://dx.doi.org/10.1083/jcb.201612067

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379957/
https://www.ncbi.nlm.nih.gov/pubmed/28254829
http://dx.doi.org/10.1083/jcb.201612067

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