Cargando…

VEGF165-induced vascular permeability requires NRP1 for ABL-mediated SRC family kinase activation

The vascular endothelial growth factor (VEGF) isoform VEGF165 stimulates vascular growth and hyperpermeability. Whereas blood vessel growth is essential to sustain organ health, chronic hyperpermeability causes damaging tissue edema. By combining in vivo and tissue culture models, we show here that...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fantin, Alessandro, Lampropoulou, Anastasia, Senatore, Valentina, Brash, James T., Prahst, Claudia, Lange, Clemens A., Liyanage, Sidath E., Raimondi, Claudio, Bainbridge, James W., Augustin, Hellmut G., Ruhrberg, Christiana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2017
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379968/ https://www.ncbi.nlm.nih.gov/pubmed/28289053 http://dx.doi.org/10.1084/jem.20160311

Ejemplares similares

NRP1 function and targeting in neurovascular development and eye disease
por: Raimondi, Claudio, et al.
Publicado: (2016)

NRP1 Regulates CDC42 Activation to Promote Filopodia Formation in Endothelial Tip Cells
por: Fantin, Alessandro, et al.
Publicado: (2015)

Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1–dependent ABL1 activation in endothelial cells
por: Raimondi, Claudio, et al.
Publicado: (2014)

VEGF(189) binds NRP1 and is sufficient for VEGF/NRP1-dependent neuronal patterning in the developing brain
por: Tillo, Miguel, et al.
Publicado: (2015)

Neuropilin 1 (NRP1) hypomorphism combined with defective VEGF-A binding reveals novel roles for NRP1 in developmental and pathological angiogenesis
por: Fantin, Alessandro, et al.
Publicado: (2014)

Imatinib may be ABL to improve anti-angiogenic therapy
por: Raimondi, Claudio, et al.
Publicado: (2015)

Evaluating Vascular Hyperpermeability-inducing Agents in the Skin with the Miles Assay
por: Brash, James T., et al.
Publicado: (2018)

VEGF188 promotes corneal reinnervation after injury
por: Brash, James T., et al.
Publicado: (2019)

VEGF signalling controls GnRH neuron survival via NRP1 independently of KDR and blood vessels
por: Cariboni, Anna, et al.
Publicado: (2011)

NRP1 and NRP2 cooperate to regulate gangliogenesis, axon guidance and target innervation in the sympathetic nervous system
por: Maden, Charlotte H., et al.
Publicado: (2012)

The Neuropilin 1 Cytoplasmic Domain Is Required for VEGF-A-Dependent Arteriogenesis
por: Lanahan, Anthony, et al.
Publicado: (2013)

Urea-Peptide Hybrids as VEGF-A(165)/NRP-1 Complex Inhibitors with Improved Receptor Affinity and Biological Properties
por: Puszko, Anna K., et al.
Publicado: (2020)

VEGF-A and neuropilin 1 (NRP1) shape axon projections in the developing CNS via dual roles in neurons and blood vessels
por: Erskine, Lynda, et al.
Publicado: (2017)

Myeloid-Derived Vascular Endothelial Growth Factor and Hypoxia-Inducible Factor Are Dispensable for Ocular Neovascularization—Brief Report
por: Liyanage, Sidath E., et al.
Publicado: (2016)

Cre toxicity in mouse models of cardiovascular physiology and disease
por: Rashbrook, Victoria S., et al.
Publicado: (2022)

Neuropilin Regulation of Angiogenesis, Arteriogenesis, and Vascular Permeability
por: Plein, Alice, et al.
Publicado: (2014)

The splicing factor YBX1 promotes the progression of osteosarcoma by upregulating VEGF(165) and downregulating VEGF(165b)
por: Quan, Bingxuan, et al.
Publicado: (2023)

Emerging roles for semaphorins and VEGFs in synaptogenesis and synaptic plasticity
por: Tillo, Miguel, et al.
Publicado: (2012)

VEGF(121)b and VEGF(165)b are weakly angiogenic isoforms of VEGF-A
por: Catena, Raúl, et al.
Publicado: (2010)

Vascularisation of the central nervous system
por: Tata, Mathew, et al.
Publicado: (2015)

Synthesis, Physicochemical and Biological Study of Gallium-68- and Lutetium-177-Labeled VEGF-A(165)/NRP-1 Complex Inhibitors Based on Peptide A7R and Branched Peptidomimetic
por: Masłowska, Katarzyna, et al.
Publicado: (2022)

The role of VEGF-A(165)b in trophoblast survival
por: Bills, Victoria L, et al.
Publicado: (2014)

VEGF, VEGF165b and EG-VEGF expression is specifically related with hormone profile in pituitary adenomas
por: Corlan, Ana Silvia, et al.
Publicado: (2019)

Tamoxifen-Activated CreERT Impairs Retinal Angiogenesis Independently of Gene Deletion
por: Brash, James T., et al.
Publicado: (2020)

VEGF binding to NRP1 is essential for VEGF stimulation of endothelial cell migration, complex formation between NRP1 and VEGFR2, and signaling via FAK Tyr407 phosphorylation
por: Herzog, Birger, et al.
Publicado: (2011)

Inhibition of retinal neovascularization by siRNA targeting VEGF(165)
por: Xia, Xiao-bo, et al.
Publicado: (2008)

Systems Pharmacology of VEGF165b in Peripheral Artery Disease
por: Clegg, Lindsay E., et al.
Publicado: (2017)

Novel Src/Abl tyrosine kinase inhibitor bosutinib suppresses neuroblastoma growth via inhibiting Src/Abl signaling
por: Bieerkehazhi, Shayahati, et al.
Publicado: (2016)

Levels of vascular endothelial growth factor-A(165b) (VEGF-A(165b)) are elevated in experimental glaucoma
por: Ergorul, Ceren, et al.
Publicado: (2008)

NRP1 and MMP9 are dual targets of RNA‐binding protein QKI5 to alter VEGF‐R/ NRP1 signalling in trophoblasts in preeclampsia
por: Yang, Xingyu, et al.
Publicado: (2021)

Src and Abl hijack the Robo1 pathway
por: Naus, Christian
Publicado: (2010)

Effects of receptor tyrosine kinase inhibitors on VEGF(165)a- and VEGF(165)b-stimulated gene transcription in HEK-293 cells expressing human VEGFR2
por: Carter, Joanne J, et al.
Publicado: (2015)

Expression of NRP-1 and NRP-2 in Endometrial Cancer
por: Oplawski, Marcin, et al.
Publicado: (2019)

Probing High Affinity Sequences of DNA Aptamer against VEGF(165)
por: Kaur, Harleen, et al.
Publicado: (2012)

Designing and Development of a Tandem Bivalent Nanobody against VEGF(165)
por: Khodabakhsh, Farnaz, et al.
Publicado: (2021)

The endogenous anti-angiogenic VEGF isoform, VEGF(165)b inhibits human tumour growth in mice
por: Rennel, E S, et al.
Publicado: (2008)

Overexpression of VEGF(121), but not VEGF(165) or FGF-1, improves oxygenation in MCF-7 breast tumours
por: Fenton, B M, et al.
Publicado: (2004)

Neural crest cell-derived VEGF promotes embryonic jaw extension
por: Wiszniak, Sophie, et al.
Publicado: (2015)

Development of a Multiplex Sandwich Aptamer Microarray for the Detection of VEGF(165) and Thrombin
por: Sosic, Alice, et al.
Publicado: (2013)

A pharmacokinetic binding model for bevacizumab and VEGF(165) in colorectal cancer patients
por: Panoilia, Eirini, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_3pp0c7has79mll81v0bbc15hte