Inflammatory monocytes require type I interferon receptor signaling to activate NK cells via IL-18 during a mucosal viral infection

The requirement of type I interferon (IFN) for natural killer (NK) cell activation in response to viral infection is known, but the underlying mechanism remains unclear. Here, we demonstrate that type I IFN signaling in inflammatory monocytes, but not in dendritic cells (DCs) or NK cells, is essenti...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Amanda J., Chen, Branson, Chew, Marianne V., Barra, Nicole G., Shenouda, Mira M., Nham, Tina, van Rooijen, Nico, Jordana, Manel, Mossman, Karen L., Schreiber, Robert D., Mack, Matthias, Ashkar, Ali A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379971/
https://www.ncbi.nlm.nih.gov/pubmed/28264883
http://dx.doi.org/10.1084/jem.20160880

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379971/
https://www.ncbi.nlm.nih.gov/pubmed/28264883
http://dx.doi.org/10.1084/jem.20160880

Ejemplares similares