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Inflammatory monocytes require type I interferon receptor signaling to activate NK cells via IL-18 during a mucosal viral infection
The requirement of type I interferon (IFN) for natural killer (NK) cell activation in response to viral infection is known, but the underlying mechanism remains unclear. Here, we demonstrate that type I IFN signaling in inflammatory monocytes, but not in dendritic cells (DCs) or NK cells, is essenti...
Autores principales: | Lee, Amanda J., Chen, Branson, Chew, Marianne V., Barra, Nicole G., Shenouda, Mira M., Nham, Tina, van Rooijen, Nico, Jordana, Manel, Mossman, Karen L., Schreiber, Robert D., Mack, Matthias, Ashkar, Ali A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379971/ https://www.ncbi.nlm.nih.gov/pubmed/28264883 http://dx.doi.org/10.1084/jem.20160880 |
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