Cargando…

Valproic Acid Protects Primary Dopamine Neurons from MPP(+)-Induced Neurotoxicity: Involvement of GSK3β Phosphorylation by Akt and ERK through the Mitochondrial Intrinsic Apoptotic Pathway

Valproic acid (VPA), a drug widely used to treat manic disorder and epilepsy, has recently shown neuroprotective effects in several neurological diseases, particularly in Parkinson's disease (PD). The goal of the present study was to confirm VPA's dose-dependent neuroprotective propensitie...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Chi, Yuan, Xianrui, Hu, Zhongliang, Liu, Songlin, Li, Haoyu, Wu, Ming, Yuan, Jian, Zhao, Zijin, Su, Jun, Wang, Xiangyu, Liao, Yiwei, Liu, Qing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380829/ https://www.ncbi.nlm.nih.gov/pubmed/28421199 http://dx.doi.org/10.1155/2017/8124501

Ejemplares similares

Sulfuretin Attenuates MPP(+)-Induced Neurotoxicity through Akt/GSK3β and ERK Signaling Pathways
por: Pariyar, Ramesh, et al.
Publicado: (2017)

Suppressing Cdk5 Activity by Luteolin Inhibits MPP(+)-Induced Apoptotic of Neuroblastoma through Erk/Drp1 and Fak/Akt/GSK3β Pathways
por: Reudhabibadh, Ratchaneekorn, et al.
Publicado: (2021)

Nesfatin-1 protects dopaminergic neurons against MPP(+)/MPTP-induced neurotoxicity through the C-Raf–ERK1/2-dependent anti-apoptotic pathway
por: Shen, Xiao-Li, et al.
Publicado: (2017)

Bacopa Protects against Neurotoxicity Induced by MPP(+) and Methamphetamine
por: Ferrucci, Michela, et al.
Publicado: (2022)

Inhibition of Microglia-Derived Oxidative Stress by Ciliary Neurotrophic Factor Protects Dopamine Neurons In Vivo from MPP(+) Neurotoxicity
por: Baek, Jeong Yeob, et al.
Publicado: (2018)

Wld(S )but not Nmnat1 protects dopaminergic neurites from MPP(+ )neurotoxicity
por: Antenor-Dorsey, Jo Ann V, et al.
Publicado: (2012)

Polygonatum sibiricum Polysaccharides Protect against MPP-Induced Neurotoxicity via the Akt/mTOR and Nrf2 Pathways
por: Huang, Si, et al.
Publicado: (2021)

Paeonolum protects against MPP(+)-induced neurotoxicity in zebrafish and PC12 cells
por: Lu, Xi-Lin, et al.
Publicado: (2015)

AHNAK as a Prognosis Factor Suppresses the Tumor Progression in Glioma
por: Zhao, Zijin, et al.
Publicado: (2017)

Roles of Autophagy in MPP(+)-Induced Neurotoxicity In Vivo: The Involvement of Mitochondria and α-Synuclein Aggregation
por: Hung, Kai-Chih, et al.
Publicado: (2014)

Effects of Apamin on MPP(+)-Induced Calcium Overload and Neurotoxicity by Targeting CaMKII/ERK/p65/STAT3 Signaling Pathways in Dopaminergic Neuronal Cells
por: Park, Jihyun, et al.
Publicado: (2022)

The Alteration of Nasopharyngeal and Oropharyngeal Microbiota in Children with MPP and Non-MPP
por: Lu, Zhiwei, et al.
Publicado: (2017)

Dopamine is not essential for the development of methamphetamine-induced neurotoxicity
por: Yuan, Jie, et al.
Publicado: (2010)

Ramelteon ameliorated 1-methyl-4-phenylpyridinium (MPP+)-induced neurotoxicity in neuronal cells in a mitochondrial-dependent pathway
por: Li, Chuo, et al.
Publicado: (2021)

MPP(+)-induced toxicity in the presence of dopamine is mediated by COX-2 through oxidative stress
por: Hsieh, Ya-Ching, et al.
Publicado: (2011)

Teaghrelin Protects SH-SY5Y Cells against MPP(+)-Induced Neurotoxicity through Activation of AMPK/SIRT1/PGC-1α and ERK1/2 Pathways
por: Jhuo, Cian-Fen, et al.
Publicado: (2020)

Echinacoside protects against MPTP/MPP(+)-induced neurotoxicity via regulating autophagy pathway mediated by Sirt1
por: Chen, Chang, et al.
Publicado: (2018)

miR‐30b protects nigrostriatal dopaminergic neurons from MPP(+)‐induced neurotoxicity via SNCA
por: Shen, Yu‐fei, et al.
Publicado: (2020)

Microglia-dependent neuroprotective effects of 4-octyl itaconate against rotenone-and MPP+-induced neurotoxicity in Parkinson’s disease
por: Xia, Ning, et al.
Publicado: (2023)

Involvement of the ERK pathway in the protective effects of glycyrrhizic acid against the MPP(+)-induced apoptosis of dopaminergic neuronal cells
por: TENG, LESHENG, et al.
Publicado: (2014)

Involvment of Cytosolic and Mitochondrial GSK-3β in Mitochondrial Dysfunction and Neuronal Cell Death of MPTP/MPP(+)-Treated Neurons
por: Petit-Paitel, Agnès, et al.
Publicado: (2009)

2013 MPP Workshop
por: Jonker, Michael
Publicado: (2014)

Inhibitory effects of curcumin and cyclocurcumin in 1-methyl-4-phenylpyridinium (MPP(+)) induced neurotoxicity in differentiated PC12 cells
por: Chakraborty, Sandeep, et al.
Publicado: (2017)

Hydralazine Protects Nigrostriatal Dopaminergic Neurons From MPP(+) and MPTP Induced Neurotoxicity: Roles of Nrf2-ARE Signaling Pathway
por: Guo, Xingfang, et al.
Publicado: (2019)

Carnitine Protects against MPP(+)-Induced Neurotoxicity and Inflammation by Promoting Primary Ciliogenesis in SH-SY5Y Cells
por: Bae, Ji-Eun, et al.
Publicado: (2022)

CLEFMA induces intrinsic and extrinsic apoptotic pathways through ERK1/2 and p38 signalling in uterine cervical cancer cells
por: Lee, Chung‐Yuan, et al.
Publicado: (2023)

Characteristics of the mitochondrial and cellular uptake of MPP(+), as probed by the fluorescent mimic, 4'I-MPP(+)
por: Mapa, Mapa S. T., et al.
Publicado: (2018)

miR-135b Plays a Neuroprotective Role by Targeting GSK3β in MPP(+)-Intoxicated SH-SY5Y Cells
por: Zhang, Jianlei, et al.
Publicado: (2017)

Neurotoxic effects in zebrafish embryos by valproic acid and nine of its analogues: the fish-mouse connection?
por: Brotzmann, Katharina, et al.
Publicado: (2020)

Proceedings of the 2019 MPP Workshop
por: Strachinescu, Sabina-Ioana, et al.
Publicado: (2019)

Knockdown lncRNA CRNDE enhances temozolomide chemosensitivity by regulating autophagy in glioblastoma
por: Zhao, Zijin, et al.
Publicado: (2021)

Chikusetsu Saponin V Attenuates MPP(+)-Induced Neurotoxicity in SH-SY5Y Cells via Regulation of Sirt1/Mn-SOD and GRP78/Caspase-12 Pathways
por: Yuan, Ding, et al.
Publicado: (2014)

Neuroprotective Effects of Alpha-Mangostin on MPP(+)-Induced Apoptotic Cell Death in Neuroblastoma SH-SY5Y Cells
por: Janhom, Prachya, et al.
Publicado: (2015)

Protection of dopamine neurons by CDNF and neurturin variant N4 against MPP(+) in dissociated cultures from rat mesencephalon
por: Jaumotte, Juliann D., et al.
Publicado: (2021)

Regulation of PGC-1α mediated by acetylation and phosphorylation in MPP+ induced cell model of Parkinson’s disease
por: Fan, Fei, et al.
Publicado: (2020)

Impaired mitochondrial biogenesis contributes to depletion of functional mitochondria in chronic MPP(+) toxicity: dual roles for ERK1/2
por: Zhu, J H, et al.
Publicado: (2012)

Dopaminergic Dysfunction in Mammalian Dopamine Neurons Induced by Simazine Neurotoxicity
por: Li, Xueting, et al.
Publicado: (2017)

A dopamine metabolite stabilizes neurotoxic amyloid-β oligomers
por: Cataldi, Rodrigo, et al.
Publicado: (2021)

Rapamycin reverses ferroptosis by increasing autophagy in MPTP/MPP(+)-induced models of Parkinson’s disease
por: Liu, Tongyu, et al.
Publicado: (2023)

Tetrahydroxystilbene Glucoside Produces Neuroprotection against 6-OHDA-Induced Dopamine Neurotoxicity
por: Huang, Chun, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_rpmtm041mcoejah5v279pbvnlg