PI3Kδ and PI3Kγ isoforms have distinct functions in regulating pro-tumoural signalling in the multiple myeloma microenvironment

Phosphoinositide-3-kinase and protein kinase B (PI3K-AKT) is upregulated in multiple myeloma (MM). Using a combination of short hairpin RNA (shRNA) lentivirus-mediated knockdown and pharmacologic isoform-specific inhibition we investigated the role of the PI3K p110γ (PI3Kγ) subunit in regulating MM...

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Detalles Bibliográficos
Autores principales: Piddock, R E, Loughran, N, Marlein, C R, Robinson, S D, Edwards, D R, Yu, S, Pillinger, G E, Zhou, Z, Zaitseva, L, Auger, M J, Rushworth, S A, Bowles, K M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380901/
https://www.ncbi.nlm.nih.gov/pubmed/28282033
http://dx.doi.org/10.1038/bcj.2017.16

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380901/
https://www.ncbi.nlm.nih.gov/pubmed/28282033
http://dx.doi.org/10.1038/bcj.2017.16

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