MKRN2 is a novel ubiquitin E3 ligase for the p65 subunit of NF-κB and negatively regulates inflammatory responses

Activation of NF-κB transcription factor is strictly regulated to prevent excessive inflammatory responses leading to immunopathology. However, it still remains unclear how NF-κB activation is negatively controlled. The PDZ-LIM domain-containing protein PDLIM2 is a nuclear ubiquitin E3 ligase target...

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Detalles Bibliográficos
Autores principales: Shin, Chanyoung, Ito, Yuma, Ichikawa, Shota, Tokunaga, Makio, Sakata-Sogawa, Kumiko, Tanaka, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380948/
https://www.ncbi.nlm.nih.gov/pubmed/28378844
http://dx.doi.org/10.1038/srep46097

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380948/
https://www.ncbi.nlm.nih.gov/pubmed/28378844
http://dx.doi.org/10.1038/srep46097

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