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Polysulfides (H(2)S(n)) produced from the interaction of hydrogen sulfide (H(2)S) and nitric oxide (NO) activate TRPA1 channels

Hydrogen sulfide (H(2)S) exerts synergistic effects with another gaseous signaling molecule nitric oxide (NO) on ion channels and vasculature. However, the mechanism of the synergy is not well understood. Here, we show that the interaction between H(2)S and NO generates polysulfides (H(2)S(n)), whic...

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Detalles Bibliográficos
Autores principales: Miyamoto, Ryo, Koike, Shin, Takano, Yoko, Shibuya, Norihiro, Kimura, Yuka, Hanaoka, Kenjiro, Urano, Yasuteru, Ogasawara, Yuki, Kimura, Hideo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380989/
https://www.ncbi.nlm.nih.gov/pubmed/28378773
http://dx.doi.org/10.1038/srep45995