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Is DNA methylation the new guardian of the genome?
BACKGROUND: It has been known for more than 100 years that aneuploidy is an essence of cancer. The question is what keeps the genome stable, thereby preventing aneuploidy. For the past 25 years, it has been proposed that p53 is the “guardian of the genome.” However, it has been shown that inactivati...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381125/ https://www.ncbi.nlm.nih.gov/pubmed/28396696 http://dx.doi.org/10.1186/s13039-017-0314-8 |