Computationally Discovered Potentiating Role of Glycans on NMDA Receptors

N-methyl-D-aspartate receptors (NMDARs) are glycoproteins in the brain central to learning and memory. The effects of glycosylation on the structure and dynamics of NMDARs are largely unknown. In this work, we use extensive molecular dynamics simulations of GluN1 and GluN2B ligand binding domains (L...

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Detalles Bibliográficos
Autores principales: Sinitskiy, Anton V., Stanley, Nathaniel H., Hackos, David H., Hanson, Jesse E., Sellers, Benjamin D., Pande, Vijay S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381272/
https://www.ncbi.nlm.nih.gov/pubmed/28378791
http://dx.doi.org/10.1038/srep44578

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381272/
https://www.ncbi.nlm.nih.gov/pubmed/28378791
http://dx.doi.org/10.1038/srep44578

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