MDM2 SNP309 polymorphism is associated with colorectal cancer risk

The human murine double minute 2 (MDM2) is known as an oncoprotein through inhibiting P53 transcriptional activity and mediating P53 ubiquitination. Therefore, the amplification of MDM2 may attenuate the P53 pathway and promote tumorigenesis. The SNP309 T>G polymorphism (rs2279744), which is loca...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Weizhi, Du, Mulong, Gu, Dongying, Zhu, Lingjun, Chu, Haiyan, Tong, Na, Zhang, Zhengdong, Xu, Zekuan, Wang, Meilin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381279/
https://www.ncbi.nlm.nih.gov/pubmed/24797837
http://dx.doi.org/10.1038/srep04851

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381279/
https://www.ncbi.nlm.nih.gov/pubmed/24797837
http://dx.doi.org/10.1038/srep04851

Ejemplares similares