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MDM2 SNP309 polymorphism is associated with colorectal cancer risk

The human murine double minute 2 (MDM2) is known as an oncoprotein through inhibiting P53 transcriptional activity and mediating P53 ubiquitination. Therefore, the amplification of MDM2 may attenuate the P53 pathway and promote tumorigenesis. The SNP309 T>G polymorphism (rs2279744), which is loca...

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Detalles Bibliográficos
Autores principales:	Wang, Weizhi, Du, Mulong, Gu, Dongying, Zhu, Lingjun, Chu, Haiyan, Tong, Na, Zhang, Zhengdong, Xu, Zekuan, Wang, Meilin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381279/ https://www.ncbi.nlm.nih.gov/pubmed/24797837 http://dx.doi.org/10.1038/srep04851

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