Siglec-7 restores β-cell function and survival and reduces inflammation in pancreatic islets from patients with diabetes

Chronic inflammation plays a key role in both type 1 and type 2 diabetes. Cytokine and chemokine production within the islets in a diabetic milieu results in β-cell failure and diabetes progression. Identification of targets, which both prevent macrophage activation and infiltration into islets and...

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Detalles Bibliográficos
Autores principales: Dharmadhikari, Gitanjali, Stolz, Katharina, Hauke, Michael, Morgan, Noel G., Varki, Ajit, de Koning, Eelco, Kelm, Sørge, Maedler, Kathrin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381285/
https://www.ncbi.nlm.nih.gov/pubmed/28378743
http://dx.doi.org/10.1038/srep45319

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381285/
https://www.ncbi.nlm.nih.gov/pubmed/28378743
http://dx.doi.org/10.1038/srep45319

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