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Yokukansan, a Kampo medicine, prevents the development of morphine tolerance through the inhibition of spinal glial cell activation in rats
BACKGROUND: Animal models have shown that glial cells (microglia and astrocytes) in the spinal cord undergo activation following peripheral injury associated with chronic pain, suggesting the involvement of these cells in pain diseases. We have previously reported that Yokukansan (YKS), a Japanese t...
Autores principales: | Takemoto, Mariko, Sunagawa, Masataka, Okada, Mayumi, Ikemoto, Hideshi, Suga, Hiroki, Katayama, Ayami, Otake, Hiroshi, Hisamitsu, Tadashi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381433/ https://www.ncbi.nlm.nih.gov/pubmed/28462096 http://dx.doi.org/10.1016/j.imr.2015.12.003 |
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