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Standard Codon Substitution Models Overestimate Purifying Selection for Nonstationary Data

Estimation of natural selection on protein-coding sequences is a key comparative genomics approach for de novo prediction of lineage-specific adaptations. Selective pressure is measured on a per-gene basis by comparing the rate of nonsynonymous substitutions to the rate of synonymous substitutions....

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Detalles Bibliográficos
Autores principales: Kaehler, Benjamin D., Yap, Von Bing, Huttley, Gavin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381540/
https://www.ncbi.nlm.nih.gov/pubmed/28175284
http://dx.doi.org/10.1093/gbe/evw308