An alternative synthesis of Vandetanib (Caprelsa™) via a microwave accelerated Dimroth rearrangement

Vandetanib is an orally available tyrosine kinase inhibitor used in the treatment of cancer. The current synthesis proceeds via an unstable 4-chloroquinazoline, using harsh reagents, in addition to requiring sequential protection and deprotection steps. In the present work, use of the Dimroth rearra...

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Detalles Bibliográficos
Autores principales: Brocklesby, Kayleigh L., Waby, Jennifer S., Cawthorne, Chris, Smith, Graham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381755/
https://www.ncbi.nlm.nih.gov/pubmed/28413233
http://dx.doi.org/10.1016/j.tetlet.2017.02.082

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381755/
https://www.ncbi.nlm.nih.gov/pubmed/28413233
http://dx.doi.org/10.1016/j.tetlet.2017.02.082

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