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An alternative synthesis of Vandetanib (Caprelsa™) via a microwave accelerated Dimroth rearrangement
Vandetanib is an orally available tyrosine kinase inhibitor used in the treatment of cancer. The current synthesis proceeds via an unstable 4-chloroquinazoline, using harsh reagents, in addition to requiring sequential protection and deprotection steps. In the present work, use of the Dimroth rearra...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381755/ https://www.ncbi.nlm.nih.gov/pubmed/28413233 http://dx.doi.org/10.1016/j.tetlet.2017.02.082 |